Question

Which of the following statement(s) regarding trafficking in eukaryotic cells is(are) CORRECT?

• A. Dynamin binds GTP and is involved in vesicle budding
• B. Dynamin is involved in cytoskeletal remodelling
• C. Dynein binds ATP and is involved in movement of organelles along microtubules
• D. Dynein binds GTP and is involved in movement of organelles along microtubules

Hint:

Membrane trafficking often relies on GTPases like dynamin for vesicle formation, while motor proteins like dynein use ATP to transport cargo along microtubules.

Answer 1

The Correct Option is A, C

Dynamin is a large GTP-binding protein that plays a crucial role in vesicle scission during endocytosis. It forms a helical collar around the neck of budding vesicles and uses the energy from GTP hydrolysis to constrict and sever the vesicle from the membrane. Therefore, statement (A) is correct.
Statement (B) is incorrect because dynamin’s primary function is in vesicle budding, not in cytoskeletal remodelling.
Dynein is a motor protein that moves cargo toward the minus end of microtubules. It uses ATP hydrolysis to generate movement along microtubules. Hence, statement (C) is correct.
Statement (D) is incorrect because dynein binds ATP, not GTP.
Thus, the correct statements are (A) and (C).