Step 1: Understanding Type 1 Diabetes mellitus.
Type 1 diabetes is characterized by the autoimmune destruction of pancreatic beta cells, which results in insulin deficiency. This is different from Type 2 diabetes, which involves insulin resistance.
Step 2: Analyzing the options.
(1) Insulin resistance: This is the hallmark of Type 2 diabetes, not Type 1.
(2) Insulin deficiency: This is the correct answer. Insulin deficiency occurs due to the loss of beta cells in the pancreas.
(3) Impaired insulin secretion: This can occur in Type 1 diabetes, but the primary hallmark is insulin deficiency.
(4) Insulin sensitivity: This is related to Type 2 diabetes and insulin resistance, not Type 1.
Step 3: Conclusion.
The hallmark of Type 1 diabetes is (2) Insulin deficiency.