Question

Which of the following is Phase-II metabolism reaction:

• A. Reduction
• B. Acetylation
• C. Hydrolysis
• D. Oxidation

Hint:

Phase-II reactions like acetylation are conjugation reactions that increase the solubility of the drug, making it easier for the body to eliminate it.

Answer 1

The Correct Option is B

Acetylation is a Phase-II metabolism reaction, also known as conjugation. In this reaction, an acetyl group is added to the drug or its metabolite, increasing its water solubility and facilitating excretion. Phase-I reactions (like oxidation, reduction, and hydrolysis) modify the drug molecule, while Phase-II reactions involve conjugation with endogenous molecules like acetyl groups, sulfate, or glucuronic acid.