Question:

Which of the following is Phase-II metabolism reaction:

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Phase-II reactions like acetylation are conjugation reactions that increase the solubility of the drug, making it easier for the body to eliminate it.
Updated On: Feb 4, 2025
  • Reduction
  • Acetylation
  • Hydrolysis
  • Oxidation
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The Correct Option is B

Solution and Explanation

Acetylation is a Phase-II metabolism reaction, also known as conjugation. In this reaction, an acetyl group is added to the drug or its metabolite, increasing its water solubility and facilitating excretion. Phase-I reactions (like oxidation, reduction, and hydrolysis) modify the drug molecule, while Phase-II reactions involve conjugation with endogenous molecules like acetyl groups, sulfate, or glucuronic acid.

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