Question

Which of the following is not a GABA derivative:

• A. Pregabalin
• B. Vigabatrin
• C. Gabapentin
• D. Rufinamide

Hint:

GABA derivatives include Pregabalin, Gabapentin, and Vigabatrin, whereas Rufinamide is a sodium channel modulator and not structurally related to GABA.

Answer 1

The Correct Option is D

Step 1: Understanding GABA derivatives. Gamma-Aminobutyric Acid (GABA) derivatives are drugs structurally related to GABA and function as central nervous system (CNS) depressants, primarily used as anticonvulsants or neuropathic pain medications. Step 2: Classification of the given drugs. - (A) Pregabalin: A GABA analog used for neuropathic pain, epilepsy, and generalized anxiety disorder. - (B) Vigabatrin: A GABA derivative that inhibits GABA transaminase, increasing GABA levels. - (C) Gabapentin: A GABA analog that modulates calcium channels, used for seizures and neuropathic pain. - (D) Rufinamide: Not a GABA derivative. It is an anticonvulsant that works by prolonging sodium channel inactivation. Step 3: Why Rufinamide is the correct answer. Unlike Pregabalin, Gabapentin, and Vigabatrin, which are structurally related to GABA, Rufinamide is a triazole derivative and does not mimic GABA activity. Instead, it stabilizes sodium channels to prevent seizures.