Question

Which of the following is a Partial Fatty acid oxidation (pFox) inhibitor:

• A. \( \text{Trimetazidine} \)
• B. \( \text{Atosiban} \)
• C. \( \text{Verapamil} \)
• D. \( \text{Nicardipine} \)

Hint:

pFox inhibitors like Trimetazidine are beneficial in chronic stable angina by improving myocardial energy efficiency. They are often used as adjunct therapy when standard treatments are insufficient.

Answer 1

The Correct Option is A

Step 1: Understanding pFox inhibitors. Partial Fatty acid oxidation (pFox) inhibitors, such as Trimetazidine, work by shifting myocardial energy metabolism from fatty acid oxidation to glucose oxidation. This is more oxygen-efficient and helps improve cardiac efficiency, especially in conditions like ischemic heart disease. 

Step 2: Explanation of Trimetazidine. Trimetazidine is the prototype pFox inhibitor. It selectively inhibits long-chain 3-ketoacyl-CoA thiolase (an enzyme involved in fatty acid oxidation), thereby enhancing glucose oxidation and reducing myocardial oxygen demand. 

Step 3: Comparison with other options. - Option \( (B) \): Atosiban is an oxytocin receptor antagonist used in preterm labor, not a pFox inhibitor. 
- Option \( (C) \): Verapamil is a calcium channel blocker used for angina and arrhythmias, not a pFox inhibitor. 
- Option \( (D) \): Nicardipine is also a calcium channel blocker and not related to fatty acid oxidation. 

Conclusion: Trimetazidine is the correct answer as a pFox inhibitor.