Sodium fluoride (NaF) is a fluoride preparation that interacts with hydroxyapatite crystals in the tooth structure to form calcium fluoride (CaF). This calcium fluoride further diffuses into the enamel, eventually forming fluorapatite crystals, which are more resistant to acid dissolution and provide enhanced protection against tooth decay.
Other fluoride preparations like stannous fluoride and amine fluoride do not interact with hydroxyapatite in the same way to form fluorapatite. Acidulated phosphate fluoride (APF) also does not primarily rely on this mechanism for fluoride incorporation.