Question

Which of the following drugs has a 1,3,4-thiadiazole ring system?

• A. Dichlorophenamide
• B. Spironolactone
• C. Acetazolamide
• D. Furosemide

Hint:

- The 1,3,4-thiadiazole ring is commonly found in drugs with carbonic anhydrase inhibition properties, like Acetazolamide. 
- Recognizing key heterocyclic rings like thiadiazole helps in identifying specific drug classes.

Answer 1

The Correct Option is C

The 1,3,4-thiadiazole ring is a heterocyclic compound containing both sulfur and nitrogen atoms, and it is found in certain pharmacologically active compounds. Among the options: 
- Acetazolamide (option C) contains a 1,3,4-thiadiazole ring in its structure. Acetazolamide is a carbonic anhydrase inhibitor, primarily used in the treatment of glaucoma, edema, and certain types of seizures. The thiadiazole ring is integral to its pharmacological activity. 

Why Other Options Are Incorrect: 
- (A) Dichlorophenamide: This drug does not contain the 1,3,4-thiadiazole ring system. 
- (B) Spironolactone: This drug contains a lactone ring system, but not a thiadiazole ring. 
- (D) Furosemide: Furosemide contains a sulfonamide group and a benzene ring, but it does not have a thiadiazole ring. 

Thus, the correct drug with the 1,3,4-thiadiazole ring system is Acetazolamide.