Question

Which of the following coenzymes is/are present in the pyruvate dehydrogenase complex?

• A. Coenzyme A
• B. Lipoate
• C. Pyridoxal phosphate
• D. Thiamine pyrophosphate

Hint:

The pyruvate dehydrogenase complex requires Coenzyme A, Lipoate, and Thiamine pyrophosphate for its enzymatic activity.

Answer 1

The Correct Option is A, B, D

Step 1: Understanding the Pyruvate Dehydrogenase Complex.
The pyruvate dehydrogenase complex catalyzes the conversion of pyruvate to acetyl-CoA and requires several coenzymes for its activity:
- Coenzyme A is involved in the transfer of the acetyl group.
- Lipoate plays a crucial role in the redox reactions during the conversion.
- Thiamine pyrophosphate is involved in the decarboxylation of pyruvate.
Step 2: Analyzing the Options.
- (A) Correct. Coenzyme A is a necessary cofactor for the pyruvate dehydrogenase complex.
- (B) Correct. Lipoate is also required for the function of the complex.
- (C) Incorrect. Pyridoxal phosphate is not involved in this complex; it is associated with amino acid metabolism.
- (D) Correct. Thiamine pyrophosphate is involved in the decarboxylation of pyruvate.
Step 3: Conclusion.
Thus, the correct answer is (A), (B), and (D).