Question:
Which of the following antimicrobial agent(s) is/are growth factor analog(s)?
Which of the following antimicrobial agent(s) is/are growth factor analog(s)?
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Growth factor analogs mimic vitamins or metabolites: Sulfa (PABA), INH (NAD), 5-FU (uracil).
Updated On: Jan 2, 2026
- 5-Fluorouracil
- Isoniazid
- Sulfanilamide
- Tetracycline
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The Correct Option is A, B, C
Solution and Explanation
Growth factor analogs mimic essential metabolites required by microbes, but their altered structure interferes with metabolic pathways.
5-Fluorouracil resembles uracil and disrupts nucleotide synthesis, so it is a pyrimidine analog. Hence, (A) is correct.
Isoniazid acts as a nicotinamide (vitamin B3) analog and inhibits mycolic acid synthesis in Mycobacterium tuberculosis, making (B) correct.
Sulfanilamide is a structural analog of para-aminobenzoic acid (PABA) and blocks folic acid synthesis, so (C) is correct.
Tetracycline, however, is not a growth factor analog; it inhibits protein synthesis by binding to the 30S ribosomal subunit, making (D) incorrect.
Thus, the correct answers are (A), (B), and (C).
5-Fluorouracil resembles uracil and disrupts nucleotide synthesis, so it is a pyrimidine analog. Hence, (A) is correct.
Isoniazid acts as a nicotinamide (vitamin B3) analog and inhibits mycolic acid synthesis in Mycobacterium tuberculosis, making (B) correct.
Sulfanilamide is a structural analog of para-aminobenzoic acid (PABA) and blocks folic acid synthesis, so (C) is correct.
Tetracycline, however, is not a growth factor analog; it inhibits protein synthesis by binding to the 30S ribosomal subunit, making (D) incorrect.
Thus, the correct answers are (A), (B), and (C).
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