Question

Which antibiotic undergoes light catalysed autoxidation:

• A. Polyene antibiotics
• B. Beta lactum antibiotics
• C. Sugar derived antibiotics
• D. Macrolide antibiotics

Hint:

Polyene antibiotics, like amphotericin B, are sensitive to light and oxygen, which can cause autoxidation. Always store them in dark conditions to preserve their efficacy.

Answer 1

The Correct Option is A

Polyene antibiotics undergo light-catalysed autoxidation, a process where exposure to light accelerates the oxidation of the antibiotic. This leads to the breakdown of the polyene structure, rendering the antibiotic less effective. This is a significant consideration in the storage and handling of such antibiotics.