Question

What is the reason for hyperglycaemia caused due to long-term thiazide therapy?

• A. \( \text{Increasing sympathetic activity} \)
• B. \( \text{Reducing insulin release} \)
• C. \( \text{Interfering with glucose utilization in tissues} \)
• D. \( \text{Increasing corticosteroid secretion} \)

Hint:

Remember that thiazides can affect electrolyte balance, including potassium, which in turn can impact insulin secretion.

Answer 1

The Correct Option is B

Long-term thiazide diuretic therapy can lead to hyperglycaemia (increased blood glucose levels) through several mechanisms. One of the key mechanisms is the impairment of insulin secretion from the pancreatic beta cells. Thiazides can affect potassium channels in these cells, which are involved in insulin release. By altering potassium levels and channel function, thiazides can reduce the amount of insulin secreted in response to glucose. While other factors like increased insulin resistance and increased hepatic glucose production may also play a role, the reduction in insulin release is a significant contributor to thiazide-induced hyperglycaemia.