The Harmonic Mean \( H \) of a set of numbers \( x_1, x_2, \dots, x_n \) is given by:
\[
H = \frac{n}{\frac{1}{x_1} + \frac{1}{x_2} + \dots + \frac{1}{x_n}}.
\]
For the numbers 3, 4, 5, and 6:
\[
H = \frac{4}{\frac{1}{3} + \frac{1}{4} + \frac{1}{5} + \frac{1}{6}} = \frac{4}{0.3333 + 0.25 + 0.2 + 0.1667} = \frac{4}{0.95} \approx 4.21.
\]