Step 1: Understanding the Concept:
The question asks for the earliest and most common indicator of pregnancy.
Step 2: Detailed Explanation:
- The Closure of the menstrual cycle, commonly known as a missed period, is the hallmark and most reliable early sign of pregnancy. This happens because the hormone progesterone, produced after conception, prevents the uterine lining from shedding.
- Morning sickness (nausea and vomiting) and Frequent urination are also common early symptoms, but they typically begin a few weeks after the missed period.
- Therefore, a missed period is considered the first sign.
Step 3: Final Answer:
The first and most dependable symptom of pregnancy is the closure of the menstrual cycle (a missed period).