Question

What impact does replacing the decalin ring with a cyclohexane ring have on the activity of HMG-CoA reductase inhibitors?

• A. 10000 fold increase in the activity
• B. 10000 fold decrease in the activity
• C. No changes in the activity
• D. Increase in the activity

Hint:

Statins: decalin ring → high affinity; cyclohexane → major activity drop.

Answer 1

The Correct Option is B

The decalin ring in statins is crucial for their interaction with HMG-CoA reductase. Replacing it with a cyclohexane ring significantly reduces hydrophobic binding and leads to a 10000-fold decrease in inhibitory activity.