When capacitors are connected in series, the total capacitance \( C_{total} \) is given by:
\[
\frac{1}{C_{total}} = \frac{1}{C_1} + \frac{1}{C_2}
\]
Substituting the values for \( C_1 = 4 \, \mu F \) and \( C_2 = 6 \, \mu F \):
\[
\frac{1}{C_{total}} = \frac{1}{4} + \frac{1}{6} = \frac{5}{12} \quad \Rightarrow \quad C_{total} = \frac{12}{5} = 2.4 \, \mu F
\]
Now, the total potential difference is distributed across the capacitors. The potential difference across a capacitor in series is given by:
\[
V_1 = V_{total} \times \frac{C_{total}}{C_1} \quad \text{and} \quad V_2 = V_{total} \times \frac{C_{total}}{C_2}
\]
Substitute the known values:
\[
V_1 = 500 \times \frac{6}{10} = 300 \, \text{V}
\]
Thus, the potential difference across the 4 μF capacitor is \( \boxed{300 \, \text{V}} \).