Question

Transcription factors that mediate the binding of RNA polymerase to DNA template are
A. TFIIA
B. TATA box
C. TFIIB
D. Small nuclear ribonucleoproteins
Choose the correct answer from the options given below:

• A. A and D
• B. A and C
• C. C and D
• D. B and D

Hint:

Focus on the roles of transcription factors in stabilizing RNA polymerase binding during transcription initiation.

Answer 1

The Correct Option is B

Transcription factors are proteins that assist in the initiation and regulation of transcription by facilitating the binding of RNA polymerase to the DNA template. Among the options:
- TFIIA: A general transcription factor that stabilizes the binding of TFIID (which includes the TATA-binding protein) to the promoter region. It is crucial for forming the transcription initiation complex. - TATA box: Not a transcription factor but a DNA sequence in the promoter region that serves as the binding site for transcription factors such as TFIID. -
TFIIB: A transcription factor that plays a role in recruiting RNA polymerase II to the promoter and stabilizing its binding during initiation. - Small nuclear ribonucleoproteins (snRNPs): These are involved in RNA splicing and do not play a direct role in transcription initiation.
Thus, the transcription factors involved in mediating the binding of RNA polymerase to the DNA template are TFIIA and TFIIB.