Question

The structural feature which is essential for both glucocorticoids and mineralocorticoids activity is

• A. 6-$\alpha$ substitution on ring B
• B. 3-keto group on ring A
• C. Double bond in the 1,2 position of ring A
• D. Without 17$\alpha$ hydroxy group

Hint:

Both glucocorticoids and mineralocorticoids require a 3-keto group for receptor binding and activity.

Answer 1

The Correct Option is B

The 3-keto group on ring A is a fundamental structural requirement for both glucocorticoid and mineralocorticoid activity. This group plays a crucial role in the binding of these hormones to their respective receptors. Alteration or removal of this group significantly diminishes hormonal activity.