We are given the sequence:
\[
2, 6, 18, 54, \ldots
\]
We can observe that each term is being multiplied by 3 to get the next term:
\[
2 \times 3 = 6, \quad 6 \times 3 = 18, \quad 18 \times 3 = 54.
\]
Therefore, the next term will be:
\[
54 \times 3 = 162.
\]
Thus, the next term in the sequence is \( 4374 \).