To answer this question, we need to understand the key concepts and distinctions between the given options: Mission, Goal, Strategy, and Objective.
Analyzing these definitions, the concept that best fits "how an entrepreneur will make his/her venture profitable and impactful" is Strategy. This is because strategy involves crafting a plan and set of actions to achieve profitability and impact, guiding the entrepreneur on what to focus on to make the venture successful.
Thus, the correct answer is Strategy.