1. Hormone X increases blood glucose: Glucagon raises glucose by promoting glycogenolysis and gluconeogenesis, correct. Insulin lowers glucose, so incorrect.
2. Hormone Y, low levels cause lethargy: Thyroxine (T4) regulates metabolism; deficiency (hypothyroidism) causes lethargy, correct.
3. Epinephrine increases glucose but is not linked to lethargy. Estradiol affects reproduction, not lethargy.
4. Thus, X = glucagon, Y = thyroxine, so the answer is (1) Glucagon, thyroxine.