Carbon, hydrogen, oxygen and nitrogen are called four big elements of living body they make up about 99% of the mass of most cells. These are lightest elements that are capable of forming covalent bonds. It is known that the strength of covalent bond is inversely related to the atomic weights of the bonded atoms. As C, H, O and N are lightest elements so the bonds they form are the strongest covalent bonds. So that the compounds formed are stable, varied in size and shapes. Carbon constitutes more than 50% of the dry matter. It has been observed that human body contains 0.5% hydrogen, 18.5% carbon, 65% oxygen and 3.3% nitrogen. Other elements are present in very lesser amount.