Question

The etiology of jaundice could be haemolytic anaemia if:

• A. Unconjugated bilirubin is found equal to conjugated bilirubin
• B. Increase in IgE level
• C. Conjugated bilirubin is found more than unconjugated bilirubin
• D. Unconjugated bilirubin is found more than conjugated bilirubin

Hint:

Haemolytic jaundice is characterized by increased unconjugated bilirubin due to excessive red blood cell breakdown. Monitor bilirubin levels to identify the type of jaundice.

Answer 1

The Correct Option is D

Step 1: Understanding haemolytic anaemia and its link to jaundice. In haemolytic anaemia, excessive destruction of red blood cells leads to an increase in the production of bilirubin. The liver may not process all of this bilirubin for conjugation, resulting in elevated levels of unconjugated bilirubin in the bloodstream. 

Step 2: Differentiating between unconjugated and conjugated bilirubin.
 - Unconjugated bilirubin: Indirect bilirubin, not yet processed by the liver for excretion. 
- Conjugated bilirubin: Direct bilirubin, processed by the liver and ready for excretion via bile. 

Step 3: Diagnostic marker. The predominance of unconjugated bilirubin in the blood is a key diagnostic marker for haemolytic jaundice, distinguishing it from other types such as obstructive or hepatocellular jaundice.