Two real functions (or signals) \(x_1(t)\) and \(x_2(t)\) are orthogonal over a given interval \([T_1, T_2]\) if their inner product is zero:
\[ \int_{T_1}^{T_2} x_1(t) x_2(t) dt = 0 \]
The term \(R_{12}\) in the options typically refers to a measure of cross-correlation. If \(R_{12}\) specifically denotes the value of this inner product (or cross-correlation at zero lag, \(R_{12}(0) = \int x_1(t)x_2(t)dt\) for energy signals over \((-\infty, \infty)\)), then the condition for orthogonality is \(R_{12}=0\).
\(R_{11}(0) = \int x_1^2(t)dt\) is the energy of signal \(x_1(t)\). \(R_{11}=0\) would mean \(x_1(t)\) is a zero signal.
Thus, \(R_{12}=0\) signifies that the functions are uncorrelated in the sense of their inner product being zero, which is the definition of orthogonality.
\[ \boxed{R_{12} = 0} \]