Step 1: Understanding the given expansion.
We are given the summation:
\[
\sum_{m=0}^{100} \binom{100}{m} (x - 3)^{100 - m} 2^m.
\]
This is the binomial expansion of \( (x - 3 + 2)^{100} \), or equivalently \( (x - 1)^{100} \).
Step 2: Expanding the expression.
Using the binomial theorem, we expand \( (x - 1)^{100} \):
\[
(x - 1)^{100} = \sum_{m=0}^{100} \binom{100}{m} x^{100 - m} (-1)^m.
\]
Thus, the general term in the expansion is:
\[
\binom{100}{m} x^{100 - m} (-1)^m.
\]
To find the coefficient of \( x^{53} \), we need the term where the exponent of \( x \) is 53. This occurs when:
\[
100 - m = 53 \quad \Rightarrow \quad m = 47.
\]
Step 3: Finding the coefficient.
When \( m = 47 \), the corresponding term is:
\[
\binom{100}{47} x^{53} (-1)^{47} 2^{47}.
\]
The coefficient of \( x^{53} \) is therefore:
\[
-\binom{100}{47} 2^{47}.
\]
Since the problem asks for the coefficient of \( x^{53} \), the answer is \( -\binom{100}{53} \), and the correct answer is (c).