Question

Replacement of 6-methoxy group of quinine with a 7-chloro substituent results in formation of ………………

• A. Cinchonine
• B. Chloroquine
• C. Amodiaquine
• D. Mefloquine

Hint:

6-methoxy → 7-chloro switch in quinine → chloroquine synthesis.

Answer 1

The Correct Option is B

Chloroquine, a synthetic antimalarial, is structurally derived from quinine by replacing the 6-methoxy group with a 7-chloro substituent, which enhances its antimalarial activity and oral efficacy.