Question

Pseudogout arthritis is caused by :

• A. \( \text{Monosodium urate} \)
• B. \( \text{Calcium pyrophosphate} \)
• C. \( \text{Calcium apatite} \)
• D. \( \text{Calcium oxalate} \)

Hint:

\textbf{Rheumatology: Crystal Arthropathies.} Remember the key difference between gout and pseudogout: gout is caused by monosodium urate crystals, while pseudogout is caused by calcium pyrophosphate crystals. These can be differentiated by joint fluid analysis under polarized light microscopy.

Answer 1

The Correct Option is B

Pseudogout, also known as calcium pyrophosphate deposition disease (CPPD) or chondrocalcinosis, is a form of arthritis characterized by the deposition of calcium pyrophosphate crystals in the joints. These crystals trigger inflammation, leading to acute pain, swelling, and stiffness, mimicking the symptoms of gout. Let's briefly look at the other options: Monosodium urate: Deposition of monosodium urate crystals in the joints is the cause of gout, not pseudogout. Calcium apatite: Deposition of calcium apatite crystals can cause other musculoskeletal conditions, such as calcific tendinitis, but it is not the primary cause of pseudogout. Calcium oxalate: Calcium oxalate crystals are commonly associated with kidney stones and are not typically involved in the pathogenesis of pseudogout. Therefore, pseudogout arthritis is caused by the deposition of calcium pyrophosphate crystals.