(A) True. By definition of 4-/8-neighborhoods on the image grid, $(x\!\pm\!1,y)$ are the horizontal neighbors and $(x,y\!\pm\!1)$ are the vertical neighbors of $(x,y)$.
(B) False. A pixel value (DN) equals the average of left and right neighbors only if a specific 1D smoothing/averaging filter has been applied. In general images, $I(x,y)$ is independent and need not equal $\tfrac{1}{2}\{I(x-1,y)+I(x+1,y)\}$.
(C) True. $(x-1,y-1)$ and $(x+1,y+1)$ are separated by $\Delta x=\Delta y=2$; they are two pixels apart diagonally and not adjacent (neither 4- nor 8-neighbors).
(D) True. In the 8-neighborhood of $(x,y)$ there are exactly four diagonal neighbors:
$(x\!\pm\!1,y\!\pm\!1)$. (The other four are the horizontal/vertical ones.)