Question

Photosensitive compound in human eye is made up of -

• A. Opsin and Retinal
• B. Opsin and Retinol
• C. Transducin and Retinene
• D. Guanosine and Retinol

Answer 1

The Correct Option is A

Correct Answer:

Option 1: Opsin and Retinal

Explanation:

The human eye contains special molecules called photoreceptors, which are responsible for detecting light. These photoreceptors are found in the retina and consist of two main types of cells: rods and cones. The rods are primarily responsible for vision in low light conditions (scotopic vision), while the cones are responsible for color vision and vision in bright light (photopic vision).

Both rods and cones contain light-sensitive compounds that allow them to detect light. These compounds are proteins that combine with a molecule called retinal, a derivative of vitamin A.

Rhodopsin (in rods):

The main photosensitive compound in rod cells is rhodopsin.

Rhodopsin is made up of two components:

Opsin: This is a large protein that is embedded in the membrane of the rod cells. It doesn’t directly absorb light but plays a role in signal transduction when light is absorbed by retinal.

Retinal: This is the light-sensitive molecule. It is a form of vitamin A that changes shape when it absorbs light. This change in shape triggers a cascade of events within the cell, eventually leading to the transmission of nerve signals to the brain.

Photopsins (in cones):

In cone cells, the photosensitive molecules are called photopsins.

Similar to rhodopsin, photopsins are composed of opsin proteins, but they are tuned to absorb different wavelengths of light (for color vision). There are three types of photopsins, each sensitive to different ranges of light wavelengths (red, green, and blue light).

How the Process Works:

Absorption of Light: When light enters the eye and hits the photoreceptor cells in the retina, it interacts with the retinal component of rhodopsin or photopsin.

Conformational Change: Upon absorbing light, retinal undergoes a conformational change from its 11-cis form to its all-trans form.

Signal Transmission: This conformational change in retinal triggers a change in the opsin protein, leading to a cascade of intracellular signaling. This signal is ultimately passed along to the brain via the optic nerve, where it is interpreted as visual information.

Why Opsin and Retinal?

Opsin is the protein part that, in combination with retinal, forms the light-sensitive structure. It determines the characteristics of the visual pigment, like its sensitivity to different wavelengths of light.

Retinal is the molecule that directly absorbs light. The key to vision is the isomerization of retinal when light is absorbed, which initiates the signal transduction pathway.

Why the Other Options Are Incorrect:

Option 2: Opsin and Retinol:

Retinol is a form of vitamin A, but it is not the form that directly interacts with opsin in the eye. Retinol is converted to retinal in the body, which is the molecule that actually absorbs light. So, retinol is not the photosensitive molecule.

Option 3: Transducin and Retinene:

Transducin is a G-protein that is involved in the signaling pathway after retinal absorbs light, but it is not part of the photosensitive compound itself. Similarly, retinene is another name for retinal but is not typically used as a separate term in this context.

Option 4: Guanosine and Retinol:

Guanosine is a nucleotide and not involved in the photosensitive process. It is involved in other cellular processes like cyclic GMP in signal transduction pathways, but it is not part of the photosensitive molecules.

As mentioned before, retinol is a precursor to retinal, but not the molecule that directly interacts with opsin in the light detection process.

Summary:

The photosensitive compound in the human eye consists of opsin and retinal. These molecules together form rhodopsin in rods and photopsins in cones. When light interacts with retinal, it causes a conformational change that activates opsin and triggers the signaling pathway that ultimately leads to vision.