Question

Organophosphate pesticides kill insects by inhibiting

• A. acetylcholinesterase
• B. carbonic anhydrase
• C. DNA polymerase
• D. pyruvate kinase

Hint:

Always associate organophosphates with inhibition of acetylcholinesterase and neurotoxicity.

Answer 1

The Correct Option is A

Step 1: Understanding the mechanism.
Organophosphate pesticides act by irreversibly inhibiting the enzyme acetylcholinesterase, which is responsible for breaking down the neurotransmitter acetylcholine.
Step 2: Consequence.
Inhibition of this enzyme causes accumulation of acetylcholine at synapses, leading to continuous nerve impulse transmission, paralysis, and ultimately death of the insect.
Step 3: Conclusion.
Hence, organophosphates kill insects by inhibiting acetylcholinesterase.