Question

Match List I with List II

	List I		List II
A	When two dosage forms have equal t max	I	When their total body clearance is constant.
B	AUC values of the two analogs can be compared to measure relative bioavailability	II	Absorption rate constants are equal
C	Urinary data is valid to measure bioavailability. III. W	III	When fraction absorbed and elimination rate is constant.
D	C max is proportional to the rate of absorption	IV	Excretion of drug and/or metabolite is related to the bioavailable dose.

Choose the correct answer from the options given below:

• A. A ‐ II, B ‐I , C ‐IV‐ , D ‐ III
• B. A ‐I , B ‐II , C ‐III , D ‐IV
• C. A ‐I, B ‐IV, C ‐III, D ‐II
• D. A ‐III , B ‐I , C ‐II , D ‐IV

Answer 1

The Correct Option is A

To match the correct pairs from List I with List II, let's analyze each statement: 

1. Statement A: "When two dosage forms have equal t_max" relates to when the absorption rate constants are equal because t_max (time to reach maximum concentration) reflects the rate at which the drug is absorbed. Therefore, it matches with "II. Absorption rate constants are equal".
2. Statement B: "AUC values of the two analogs can be compared to measure relative bioavailability" directly matches with "I. When their total body clearance is constant", as Area Under the Curve (AUC) is a measure of the total drug exposure and is used for comparing bioavailability under the assumption that clearance remains unchanged.
3. Statement C: "Urinary data is valid to measure bioavailability" fits "IV. Excretion of drug and/or metabolite is related to the bioavailable dose." Urinary excretion data can reflect the amount of drug absorbed if the fraction absorbed and constant elimination is assumed.
4. Statement D: "C_max is proportional to the rate of absorption" is appropriate with "III. When fraction absorbed and elimination rate is constant." C_max, the peak concentration, is influenced by the rate and extent of absorption.

Thus, the correct matching is:

A	When two dosage forms have equal tmax	II	Absorption rate constants are equal
B	AUC values of the two analogs can be compared to measure relative bioavailability	I	When their total body clearance is constant.
C	Urinary data is valid to measure bioavailability	IV	Excretion of drug and/or metabolite is related to the bioavailable dose.
D	Cmax is proportional to the rate of absorption	III	When fraction absorbed and elimination rate is constant.

Therefore, the correct answer is: A ‐ II, B ‐ I, C ‐ IV, D ‐ III.