Step 1: Understand the region \( U \).
The region \( U \) is defined by the inequality \( x + y \leq 2 \). This is a half-plane bounded by the line \( x + y = 2 \).
Step 2: Minimize \( f(x, y) = (x - 1)^4 + (y - 2)^4 \).
To minimize \( f(x, y) \), we look for the point in \( U \) where the function \( f(x, y) \) takes its minimum value. Notice that the function \( f(x, y) \) is a sum of two fourth powers, which are minimized when \( x = 1 \) and \( y = 2 \), i.e., the point closest to the origin of the function's definition.
Step 3: Check if \( (1, 2) \) lies in the region \( U \).
Substituting \( x = 1 \) and \( y = 2 \) into the inequality \( x + y \leq 2 \), we get:
\[
1 + 2 = 3 \quad \text{which is greater than} \quad 2.
\]
Thus, the point \( (1, 2) \) is not inside the region \( U \).
Step 4: Find the closest point on the boundary.
The point on the boundary closest to \( (1, 2) \) is the point where the line \( x + y = 2 \) intersects the line joining \( (1, 2) \) and the origin. By geometry, the closest point on the boundary is \( (1, 1) \).
Step 5: Compute \( f(1, 1) \).
Substitute \( (x, y) = (1, 1) \) into \( f(x, y) \):
\[
f(1, 1) = (1 - 1)^4 + (1 - 2)^4 = 0 + 1 = 1.
\]
Thus, the minimum value of \( f(x, y) \) over \( U \) is \( \boxed{1} \).