Question

In a drug discovery process:
1. Lead optimization
2. Target selection
3. Lead findings

• A. 3-2-1
• B. 1-2-3
• C. 2-3-1
• D. 3-1-2

Hint:

In drug discovery: Identify the target (2), find a lead compound (3), and optimize it (1) for better activity and safety.

Answer 1

The Correct Option is C

- Drug discovery is a step-wise process that begins with identifying the biological origin of the disease, followed by screening and optimizing chemical candidates.
- The first step is Target Selection, where a biological molecule (usually a protein) involved in a disease is chosen as a potential site for drug action. This target should be validated to confirm its role in the disease.
- The next step is Lead Finding, which involves screening of chemical libraries or natural sources to identify compounds (leads) that show biological activity against the selected target.
- The final step in this sequence is Lead Optimization, where the chemical structure of lead compounds is modified to enhance potency, selectivity, pharmacokinetics, and reduce toxicity.
- Hence, the correct order in the drug discovery process is:
Target Selection → Lead Finding → Lead Optimization = 2-3-1