I am the family face; flesh perishes. I live on, projecting trait and trace through time to times anon, and leaping from place to place over oblivion. So wrote Thomas Hardy in his poem, Heredity, describing direct descent of life from one generation to the next. Indeed, the poem reflects the DNA in our genome. Dr.Drew Endy of MIT quoted this when he described how people at the J. Craig Venter Institute (JCVI) bypass nature’s constraint of direct descent. Scientists there have used chemistry and biochemistry to produce the first synthetic genome in the laboratory. They chemically synthesized many fragments of the DNA, encoding the 582,970-units-long genome of a bacterium called Mycoplasma genitalium. Next, they assembled these fragments in perfect order to generate the genome of the bacterium. The DNA sequence of the synthetic one was confirmed to be identical to the natural one. While the DNA pieces were synthesized chemically, the stitching together was done using the biochemical machinery of a host cell. About 100 pieces of the genome, each 5000-7000 units long in DNA sequence, were first joined to produce 25 sub-assemblies, each about 24000 base pairs long. These were then introduced into the bacterium E. coli to produce sufficient DNA for the next steps. Next, they repeated the procedure to generate large fragments comprising l/4th of the whole genome of M.genitalium. Now, they used the clever trick of exploiting the process called homologous recombination. This is a basic essential process in every cell, which physically rearranges the two strands of DN The JCVI researchers inserted the synthesized DNA fragments into yeast and utilized its homologous recombination ability to generate the whole 580,000 long genome of M.genitalium in one step. This is clearly a landmark work that leads into the brave new world of synthesizing life itself in the laboratory. It was hardly 200 years ago when Friedrich Wohler synthesized urea, an organic molecule, in the chemical laboratory, thus throwing out the notion of ‘vital forces’ involved in the components of living organisms. What is the next step, making life itself in the lab, bypassing nature? With single cell organisms like M.genitalium, it might not be far away. It is now possible in the lab to do so, by inserting the genome into a ‘host’ cell and asking the latter to make the bacterium of your choice. If only we find a way to insert the bacterial genome into this proto-cell, and somehow trigger it to make the bacterium itself! We would have chemically created life in the la This is not a pipedream; JCVI scientists are already on the job, and my bet is they will do it within a few years. This surely raises ethical questions, a matter that JCVI is keenly aware of and is already engaged in with ethicists. Even their present work on M.genitalium was done with prior approval of ethical experts. But then, today it is M.genitalium, tomorrow it could be a more advanced, multi-cellular organism, and that could flummox even the ethicist. Assisted reproduction, which is the other side of the coin and truly a recently initiated technology, has become ethically and morally acceptable. Cloning of Dolly, the sheep, has not raised any outrage, but cloning a human certainly does.

Question

I am the family face; flesh perishes. I live on, projecting trait and trace through time to times anon, and leaping from place to place over oblivion. So wrote Thomas Hardy in his poem, Heredity, describing direct descent of life from one generation to the next. Indeed, the poem reflects the DNA in our genome. Dr.Drew Endy of MIT quoted this when he described how people at the J. Craig Venter Institute (JCVI) bypass nature’s constraint of direct descent. Scientists there have used chemistry and biochemistry to produce the first synthetic genome in the laboratory. They chemically synthesized many fragments of the DNA, encoding the 582,970-units-long genome of a bacterium called Mycoplasma genitalium. Next, they assembled these fragments in perfect order to generate the genome of the bacterium. The DNA sequence of the synthetic one was confirmed to be identical to the natural one. While the DNA pieces were synthesized chemically, the stitching together was done using the biochemical machinery of a host cell. About 100 pieces of the genome, each 5000-7000 units long in DNA sequence, were first joined to produce 25 sub-assemblies, each about 24000 base pairs long. These were then introduced into the bacterium E. coli to produce sufficient DNA for the next steps. Next, they repeated the procedure to generate large fragments comprising l/4th of the whole genome of M.genitalium. Now, they used the clever trick of exploiting the process called homologous recombination. This is a basic essential process in every cell, which physically rearranges the two strands of DN The JCVI researchers inserted the synthesized DNA fragments into yeast and utilized its homologous recombination ability to generate the whole 580,000 long genome of M.genitalium in one step.  This is clearly a landmark work that leads into the brave new world of synthesizing life itself in the laboratory. It was hardly 200 years ago when Friedrich Wohler synthesized urea, an organic molecule, in the chemical laboratory, thus throwing out the notion of ‘vital forces’ involved in the components of living organisms. What is the next step, making life itself in the lab, bypassing nature? With single cell organisms like M.genitalium, it might not be far away. It is now possible in the lab to do so, by inserting the genome into a ‘host’ cell and asking the latter to make the bacterium of your choice. If only we find a way to insert the bacterial genome into this proto-cell, and somehow trigger it to make the bacterium itself! We would have chemically created life in the la This is not a pipedream; JCVI scientists are already on the job, and my bet is they will do it within a few years.  This surely raises ethical questions, a matter that JCVI is keenly aware of and is already engaged in with ethicists. Even their present work on M.genitalium was done with prior approval of ethical experts. But then, today it is M.genitalium, tomorrow it could be a more advanced, multi-cellular organism, and that could flummox even the ethicist. Assisted reproduction, which is the other side of the coin and truly a recently initiated technology, has become ethically and morally acceptable. Cloning of Dolly, the sheep, has not raised any outrage, but cloning a human certainly does.

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\(\text{The Politics of Change}\)	\(\text{The Change in Politics}\)	\(\text{Politics and Change:}\) A Global Perspective}
In "The Politics of Change," political analyst Dr. Emily Harper examines the dynamics of social movements and their impact on policy reform. Through detailed case studies, she explores how grassroots organizations, protests, and advocacy campaigns shape public opinion and influence lawmakers. Dr. Harper provides insights into the strategies that successful movements employ and discusses the challenges they face in a complex political landscape. She discusses key strategies, such as coalition-building, media engagement, and the use of digital platforms to amplify voices.	This book by veteran journalist Mark Stevens investigates the shifting political landscape in the 21st century. Focusing on major elections, emerging political parties, and the role of social media, Stevens analyzes how technology and demographics are transforming political engagement and voter behaviour. Through interviews with political leaders, campaign strategists, and everyday voters, Stevens uncovers how demographic shifts and technological advancements are reshaping political discourse in urban areas. He analyzes the implications of these changes for traditional political institutions and explores how movements like #MeToo and Black Lives Matter have disrupted conventional narratives.	In this insightful work, international relations scholar Dr. Anika Patel presents a global analysis of political change across various regions. She explores the factors that drive political transitions, including economic shifts, cultural movements, and international influences. Dr. Patel emphasizes the interconnectedness of global politics and how local changes can have far-reaching implications. She analyzes various factors driving political transitions, including economic upheaval, cultural shifts, and the impact of globalization. She provides case studies from diverse regions, such as the Arab Spring, democratic movements in Latin America, and shifts in power in Asia. The book serves as a vital resource for understanding the complexities of political evolution in a rapidly changing world.

Why does the author refer to Thomas Hardy’s poem?

The Correct Option is B

Solution and Explanation

What did the scientists at JCVI do?

The Correct Option is A

Solution and Explanation

What was the outcome of their research?

The Correct Option is D

Solution and Explanation

The DNA pieces of the synthetic genome were stitched together by using

The Correct Option is B

Solution and Explanation

What is the author’s gut feeling?

The Correct Option is

Solution and Explanation

Which of the following words aptly substitutes ‘flummox’ as used in the passage?

The Correct Option is C

Solution and Explanation

According to the passage, which of the following statements is not true?

The Correct Option is D

Solution and Explanation

A recently initiated technology, which is ethically acceptable, is

The Correct Option is C

Solution and Explanation

According to the author’s opinion, what would be the result of cloning a human being?

The Correct Option is A

Solution and Explanation

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