Question

Hemophilia A is caused due to the reduction in the quantity or activity of which of the following clotting factors?

• A. Vitamin - K
• B. Clotting factor - IV
• C. Clotting factor- VIII
• D. Clotting factor-IX

Answer 1

The Correct Option is C

Hemophilia A is a genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding. This condition is caused by a deficiency in a specific clotting factor, which results in prolonged bleeding.

1. Understanding Clotting Factors:

   The human body relies on several proteins known as clotting factors to help blood clot effectively. These factors are identified using Roman numerals, such as Factor I, Factor II, etc. Clotting Factors VIII and IX are part of this group.

2. Identifying Hemophilia A:

   Hemophilia A is specifically caused by a deficiency or reduced activity of Clotting Factor VIII. This deficiency is usually hereditary and leads to the clinical symptoms associated with hemophilia.

3. Reasoning and Justifying the Correct Answer:

   Each option needs to be examined:

   1. Vitamin - K:

      Vitamin K is essential for the synthesis of multiple clotting factors, but it is not directly associated with Hemophilia A.

   2. Clotting Factor - IV:

      Clotting Factor IV is Calcium, which plays a role in the clotting process but is not a direct cause of Hemophilia A.

   3. Clotting Factor - VIII:

      As indicated, Hemophilia A is caused by a deficit of Clotting Factor VIII, confirming this option is the correct answer.

   4. Clotting Factor - IX:

      Deficiency in Clotting Factor IX leads to Hemophilia B, not Hemophilia A.

4. Conclusion:

   The correct answer to the question is Clotting Factor - VIII, as its deficiency is specifically related to Hemophilia A.

Therefore, the answer is Clotting Factor - VIII.