Question

Given below are two statements:
Statement I: Progressive chronic destruction of more than 90% of adrenal cortex on both sides causes Addison's disease.
Statement II: Tuberculosis and metastatic cancers of the adrenal glands are implicated in the majority of cases of Addison’s disease.
In the light of the above statements, choose the correct answer from the options given below:

• A. Both Statement I and Statement II are true
• B. Both Statement I and Statement II are false
• C. Statement I is true but Statement II is false
• D. Statement I is false but Statement II is true

Hint:

In Addison’s disease, autoimmune adrenalitis is the most common cause of adrenal insufficiency, rather than tuberculosis or metastatic cancers.

Answer 1

The Correct Option is C

- Statement I is true. Addison’s disease occurs due to the progressive destruction of more than 90% of the adrenal cortex. This destruction leads to insufficient production of adrenal hormones, such as cortisol and aldosterone, causing the clinical symptoms of Addison's disease.
- Statement II is false. While tuberculosis and metastatic cancers of the adrenal glands can cause Addison’s disease, they do not account for the majority of cases. The most common cause of Addison’s disease is autoimmune adrenalitis, where the body's immune system attacks the adrenal glands. Thus, the correct answer is (3) Statement I is true but Statement II is false.