Question

For which of the following human diseases was a transgenic model not developed?

• A. AIDS
• B. Cancer
• C. Cystic Fibrosis
• D. Rheumatoid arthritis

Answer 1

The Correct Option is A

Transgenic models are organisms, usually mice, that have been genetically modified to carry genes from other organisms, often used to study diseases and develop treatments. Let’s evaluate each option:

(1) AIDS: While there are various animal models used to study HIV/AIDS, a transgenic model for AIDS specifically has not been developed in the same way as for some other diseases. The HIV virus does not have a natural animal model due to species-specific barriers. Although there are transgenic mice models used to study some aspects of HIV, they are not as widely used or as effective as for other diseases.

(2) Cancer: Transgenic models for cancer have been widely developed, particularly in mice. These models are essential in studying cancer’s progression and testing treatments.

(3) Cystic Fibrosis: Transgenic models have been developed for cystic fibrosis. CFTR (Cystic Fibrosis Transmembrane Regulator) gene knockout mice have been used to study the disease and develop treatments.

(4) Rheumatoid arthritis: Transgenic models for rheumatoid arthritis have also been developed. These models are used to study autoimmune responses and test therapies.

Thus, the correct answer is (1) AIDS, as a specific transgenic model for AIDS has not been as widely developed as for the other diseases listed.

Answer 2

Developing a transgenic model for AIDS has been challenging due to the complex nature of the HIV virus. However, transgenic models have been developed for cancer, cystic fibrosis, and rheumatoid arthritis.