Question

For very weak acidic drugs, with pKa >8.

• A. They are unionized at all pH, hence absorption is rapid and independent of GI pH
• B. They are affected by changes in pH, hence absorption is pH dependent
• C. They are ionized in the entire pH range of GIT, hence poorly absorbed from GIT
• D. They are ionized in the gastric pH, hence better absorbed from the stomach

Answer 1

The Correct Option is A

The correct option is (A): They are unionized at all pH, hence absorption is rapid and independent of GI pH