Question

Following statement is correct with respect to voltage sensitive calcium channels:

• A. L-type Blocker : Nifedipine
• B. T-type Blocker : Verapamil
• C. N-type Blocker : Mibefradil
• D. R-type Blocker : Diltiazem

Answer 1

The Correct Option is A

The question asks about voltage-sensitive calcium channels and their blockers. Voltage-sensitive calcium channels are crucial in various physiological processes, and their blockers are used primarily in cardiovascular pharmacology. Let's go through each option to identify the correct relationship between calcium channel types and their blockers:

1. L-type Blocker: Nifedipine
   • L-type calcium channels are widely present in cardiac and smooth muscle cells and are responsible for the prolonged action potential phases.
   • Nifedipine is a dihydropyridine calcium channel blocker primarily targeting L-type calcium channels.
   • L-type channels are crucial for integrating electrical and biochemical signals in cells.
   • This statement is correct.
2. T-type Blocker: Verapamil
   • T-type calcium channels are low-voltage-activated channels and contribute to pacemaker activities in cardiac and neuronal tissue.
   • Verapamil is generally known to primarily block L-type calcium channels, not T-type channels.
   • This statement is incorrect.
3. N-type Blocker: Mibefradil
   • N-type calcium channels are predominantly found in neurons and play a role in neurotransmitter release.
   • Although Mibefradil can affect multiple types of calcium channels, it is not specifically recognized as an N-type blocker.
   • This statement is incorrect.
4. R-type Blocker: Diltiazem
   • R-type channels are less well-characterized but are involved in neuronal activities.
   • Diltiazem is commonly known to block L-type calcium channels rather than R-type channels.
   • This statement is incorrect.

Thus, the correct answer is L-type Blocker : Nifedipine, which accurately describes the relationship between L-type calcium channels and the specific blocker.