Let's analyze the options:
- Oxygen, Nitrogen, and Carbon are all gaseous elements in the periodic table and are essential for life in various forms.
- Helium, while a gas, is inert and does not play a biological role like the others.
Thus, Helium is the odd one out as it does not participate in life-supporting processes like Oxygen, Nitrogen, and Carbon.
Therefore, the correct answer is \( \boxed{4} \).