Find the missing number in the given figure.
\[
\begin{array}{|c|c|c|}
\hline
5 & 2 & 21 \\
\hline
6 & 3 & 27 \\
\hline
4 & 1 & ? \\
\hline
\end{array}
\]
Show Hint
For number matrix problems:
\begin{itemize}
\item Check row-wise and column-wise patterns,
\item Look for multiplication followed by addition or subtraction,
\item Observe changes in constants across rows.
\end{itemize}