Question

Etoposide and Teniposide are the semi-synthetic derivatives of:

• A. Podophyllotoxin
• B. Digoxin
• C. Vincristine
• D. Taxol

Hint:

Podophyllotoxin is a precursor for the synthesis of key anticancer drugs like Etoposide and Teniposide, which work by inhibiting DNA synthesis in rapidly dividing cells.

Answer 1

The Correct Option is A

Etoposide and Teniposide are semi-synthetic derivatives of Podophyllotoxin, a natural compound derived from the Mayapple plant. These derivatives are used as chemotherapy agents, especially in the treatment of various cancers, such as testicular cancer and small cell lung cancer.