Question

During anaerobic respiration, pyruvate undergoes decarboxylation in presence of enzyme pyruvate decarboxylase. Which of the following coenzymes and cofactors respectively are required in this reaction?

• A. Acetyl Co-A and Mg$^{++}$
• B. Acetyl Co-A and Zn$^{++}$
• C. Co-enzyme Q and Mg$^{++}$
• D. Thiamine pyrophosphate and Zn$^{++}$

Hint:

Vitamin B$_1$ (thiamine) is essential for decarboxylation reactions.

Answer 1

The Correct Option is D

Step 1: Understanding anaerobic decarboxylation.
In anaerobic respiration, pyruvate is decarboxylated to acetaldehyde by the enzyme pyruvate decarboxylase.
Step 2: Required coenzyme and cofactor.
This enzyme requires thiamine pyrophosphate (TPP) as a coenzyme and Zn$^{++}$ as a cofactor for its activity.
Step 3: Conclusion.
Thus, the correct pair is Thiamine pyrophosphate and Zn$^{++$}.