Question

Drug interaction between _______ and _________ is a beneficial interaction.

• A. \( \text{Erythromycin, digoxin} \)
• B. \( \text{Ramipril, haloperidol} \)
• C. \( \text{Adrenaline, xylocaine} \)
• D. \( \text{MAOI, fluoxetine} \)

Hint:

Think of the dentist's office – they often mix epinephrine with lidocaine to make the numbing last longer in one spot. That's a classic beneficial interaction.

Answer 1

The Correct Option is C

A beneficial drug interaction is one where the combined effect of two drugs is greater than the sum of their individual effects or where one drug enhances the therapeutic effect or reduces the adverse effects of another. - Erythromycin and digoxin: Erythromycin can inhibit the metabolism of digoxin, leading to increased digoxin levels and potentially digoxin toxicity. This is generally considered an adverse interaction. - Ramipril and haloperidol: Ramipril (an ACE inhibitor) and haloperidol (an antipsychotic) do not typically have a synergistic beneficial interaction. There might be concerns regarding hypotension or QTc prolongation, making this interaction potentially harmful or requiring careful monitoring. - Adrenaline (epinephrine) and xylocaine (lidocaine): Adrenaline is often co-administered with local anesthetics like lidocaine. Adrenaline causes vasoconstriction at the injection site, which reduces the systemic absorption of lidocaine, prolongs its local anesthetic effect, and decreases the risk of systemic toxicity. This is a beneficial interaction. - MAOI (Monoamine Oxidase Inhibitor) and fluoxetine (SSRI): Combining these drugs can lead to a dangerous condition called serotonin syndrome, characterized by symptoms like agitation, confusion, tachycardia, and hyperthermia. This is a harmful interaction. Therefore, the beneficial drug interaction among the given options is between adrenaline and xylocaine.