Step 1: Represent the numbers.
We have four numbers: $x$, $y$, $x+y$, and $x-y$. Their sum is
\[
S = x + y + (x+y) + (x-y) = 3x + y.
\]
Step 2: Use Statement I.
All four numbers must be prime. That means:
- $x$ is prime.
- $y$ is prime.
- $x+y$ is prime.
- $x-y$ is prime.
Now $x-y$ is prime → $x > y$.
Step 3: Try small primes.
Let $y=2$, the smallest prime. Then $x-y=x-2$ must be prime. If $x=5$, then $x-y=3$ (prime), $x+y=7$ (prime). All four are prime: $x=5$, $y=2$, $x+y=7$, $x-y=3$.
Step 4: Compute the sum.
\[
S = 5 + 2 + 7 + 3 = 17.
\]
Thus, using Statement I alone, we uniquely determine the sum as 17.
Step 5: Check Statement II.
“The arithmetic mean > 4” only gives $S/4>4 \Rightarrow S>16$. Many possibilities remain; the sum is not uniquely determined.
\[
\boxed{\text{Hence only Statement I is sufficient.}}
\]