Step 1: Recall the structure of chromatin.
Chromatin is the genetic material present in the nucleus of eukaryotic cells.
It appears as a thread-like structure during interphase.
Step 2: Identify the components of chromatin.
Chromatin consists of:
DNA (a nucleic acid), which carries genetic information.
Proteins, mainly histones and some non-histone proteins, which help in packaging and regulation of DNA.
Step 3: Eliminate incorrect options.
Only nucleic acid — incorrect, proteins are essential for DNA packaging.
Only protein — incorrect, DNA is the genetic material.
None of these — incorrect.
Hence, the correct answer is
\[
\boxed{\text{Nucleic acid and protein}}
\]