Step 1: Understand the meaning of "DEPLETE".
To \textit{deplete} means to reduce the quantity or number of something significantly, especially resources or strength.
Step 2: Analyze the options.
DESTROY: Means to completely ruin or eliminate something.
JOY: Opposite in meaning, unrelated.
EXHAUST: Means to use up something fully — fits best.
FINISH: Close in meaning, but not as precise as \textit{exhaust} in the context of resources.