Question

Biological activity of synthetic adrenaline is almost:

• A. 25% of S-adrenaline
• B. 25% of R-adrenaline
• C. 50% of S-adrenaline
• D. 50% of Natural R-adrenaline

Hint:

Biological activity is highly dependent on stereochemistry, as only specific enantiomers interact effectively with biological receptors.

Answer 1

The Correct Option is D

Step 1: Understanding adrenaline's stereoisomers and activity. Adrenaline exists as stereoisomers, and its biological activity is dependent on the stereochemistry. The natural adrenaline (R-enantiomer) is more biologically active compared to the synthetic mixture, which usually contains both R and S enantiomers. 

Step 2: Synthetic adrenaline's biological activity. Synthetic adrenaline is typically a racemic mixture (50% R and 50% S). Since only the R-enantiomer is biologically active, the biological activity of synthetic adrenaline is approximately 50% of the natural R-adrenaline.