According to homeopathic principles, substances that are highly toxic or capable of causing significant harm in their crude state should not be proven on healthy volunteers in their material (crude or physiological dose) form. To mitigate the risk of severe adverse effects, such substances are prepared in a potentiated form through serial dilution and succussion. This process is believed to reduce the toxic effects while enhancing the dynamic medicinal power of the substance, making it safer for proving and subsequent therapeutic use based on the Law of Similars.
Proving a highly toxic substance in its crude form or physiological dose would be unethical and potentially dangerous to the provers. Potentisation is the method by which homeopathy handles such substances for both proving and treatment.