Question

Antibody binds to antigen in solution through

• A. ionic interactions.
• B. hydrogen bonds.
• C. van der Waals interactions.
• D. hydrophobic interactions.

Hint:

In antibody-antigen binding, hydrogen bonds are the most critical non-covalent interactions that provide specificity and strength to the binding.

Answer 1

The Correct Option is A, B, C, D

Antibodies are proteins produced by the immune system to identify and neutralize foreign objects like bacteria and viruses. They are able to bind to antigens, which are specific molecules on the surface of these foreign objects, through various types of interactions. These interactions include:

1. Ionic Interactions: These occur between charged groups on the antigen and antibody. Positively charged amino acid residues in the antibody can form ionic bonds with negatively charged regions of the antigen, and vice versa. These interactions are generally strong and contribute significantly to binding specificity.
2. Hydrogen Bonds: Hydrogen bonds form when a hydrogen atom is shared between two electronegative atoms, such as nitrogen or oxygen. In the context of antibodies, these bonds aid in the formation of secondary structure and help stabilize the binding between antigen and antibody by providing additional specificity.
3. Van der Waals Interactions: These are weak, non-covalent interactions due to transient electric charges between closely positioned atoms. While individually weak, when numerous van der Waals interactions occur together, they can significantly contribute to the overall binding of the antibody to the antigen.
4. Hydrophobic Interactions: Many binding sites involve hydrophobic amino acids. When an antibody binds to an antigen, hydrophobic side chains are often buried, leading to a release of ordered water molecules and an increase in entropy, which drives the binding process.

All these interactions together lead to a strong and specific binding between an antibody and an antigen. The correct answer is that antibody binds to antigen in solution through ionic interactions, hydrogen bonds, van der Waals interactions, and hydrophobic interactions.