Aneuploidy is a chromosomal disorder where chromosome number is not the exact copy of its haploid set of chromosomes, due to : (a) Substitution (b) Addition (c) Deletion (d) Translocation (e) Inversion Choose the most appropriate answer from the options given below
Aneuploidy refers to an abnormal number of chromosomes, which is not a multiple of the haploid set. This arises due to errors during chromosome segregation in meiosis. Addition (B) and Deletion (C): These directly lead to aneuploidy. Nondisjunction, where chromosomes fail to separate correctly, can result in the addition or deletion of chromosomes in gametes. Substitution (A): Involves replacing one nucleotide with another and does not change the chromosome number. Translocation (D): Involves the transfer of a segment of a chromosome to a nonhomologous chromosome. While potentially causing other genetic disorders, balanced translocations do not directly cause aneuploidy because the total number of chromosomes remains the same. Inversion (E): A segment of the chromosome is reversed end-to-end. This doesn’t change the chromosome number.
